Carbon–Carbon Bond Cleavage Reaction: Synthesis of Multisubstituted Pyrazolo[1,5‑a]pyrimidines

Carbon–Carbon Bond Cleavage Reaction: Synthesis of Multisubstituted Pyrazolo[1,5‑a]pyrimidines

A new carbon–carbon bond cleavage reaction was developed for the efficient synthesis of multisubstituted pyrazolo­[1,5-a]­pyrimidines. This base induced reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields of the pyrazolo­[1,5-a]­pyrimidines.

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Veröffentlicht in:Journal of organic chemistry 2015-07, Vol.80 (13), p.6885-6889
Hauptverfasser: Saikia, Pallabi, Gogoi, Sanjib, Boruah, Romesh C
Format: Artikel
Sprache:eng
Schlagworte:
Carbon - chemistry
Ketones - chemistry
Molecular Structure
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
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Zusammenfassung:A new carbon–carbon bond cleavage reaction was developed for the efficient synthesis of multisubstituted pyrazolo­[1,5-a]­pyrimidines. This base induced reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields of the pyrazolo­[1,5-a]­pyrimidines.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00933