Safety of cranial radiotherapy concurrent with tyrosine kinase inhibitors in non-small cell lung cancer patients: A systematic review
Highlights • Systematic review on neurotoxicity of TKI and concurrent cranial radiation in NSCLC. • ALK: no data, concurrent EGFR–TKI and WBRT no increased neurotoxicity. • WBRT combined with SRS and concurrent EGFR–TKI: increased neurotoxicity. • Only one phase I study with solely NSCLC patients wi...
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| Veröffentlicht in: | Cancer treatment reviews 2015-07, Vol.41 (7), p.634-645 |
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| container_title | Cancer treatment reviews |
| container_volume | 41 |
| creator | Hendriks, Lizza E.L Schoenmaekers, Janna Zindler, Jaap D Eekers, Danielle B.P Hoeben, Ann De Ruysscher, Dirk K.M Dingemans, Anne-Marie C |
| description | Highlights • Systematic review on neurotoxicity of TKI and concurrent cranial radiation in NSCLC. • ALK: no data, concurrent EGFR–TKI and WBRT no increased neurotoxicity. • WBRT combined with SRS and concurrent EGFR–TKI: increased neurotoxicity. • Only one phase I study with solely NSCLC patients with activating EGFR -mutation. • Only two studies with extensive neurocognitive function testing. |
| doi_str_mv | 10.1016/j.ctrv.2015.05.005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0305-7372 |
| ispartof | Cancer treatment reviews, 2015-07, Vol.41 (7), p.634-645 |
| issn | 0305-7372 1532-1967 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ALK Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - radiotherapy Cranial Irradiation Cranial radiotherapy Disease Progression EGFR Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Neurotoxicity NSCLC Protein Kinase Inhibitors - therapeutic use Tyrosine kinase inhibitor |
| title | Safety of cranial radiotherapy concurrent with tyrosine kinase inhibitors in non-small cell lung cancer patients: A systematic review |
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