Safety of cranial radiotherapy concurrent with tyrosine kinase inhibitors in non-small cell lung cancer patients: A systematic review

Highlights • Systematic review on neurotoxicity of TKI and concurrent cranial radiation in NSCLC. • ALK: no data, concurrent EGFR–TKI and WBRT no increased neurotoxicity. • WBRT combined with SRS and concurrent EGFR–TKI: increased neurotoxicity. • Only one phase I study with solely NSCLC patients wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer treatment reviews 2015-07, Vol.41 (7), p.634-645
Hauptverfasser:	Hendriks, Lizza E.L, Schoenmaekers, Janna, Zindler, Jaap D, Eekers, Danielle B.P, Hoeben, Ann, De Ruysscher, Dirk K.M, Dingemans, Anne-Marie C
Format:	Artikel
Sprache:	eng
Schlagworte:	ALK Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - radiotherapy Cranial Irradiation Cranial radiotherapy Disease Progression EGFR Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Neurotoxicity NSCLC Protein Kinase Inhibitors - therapeutic use Tyrosine kinase inhibitor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Systematic review on neurotoxicity of TKI and concurrent cranial radiation in NSCLC. • ALK: no data, concurrent EGFR–TKI and WBRT no increased neurotoxicity. • WBRT combined with SRS and concurrent EGFR–TKI: increased neurotoxicity. • Only one phase I study with solely NSCLC patients with activating EGFR -mutation. • Only two studies with extensive neurocognitive function testing.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.05.005