Ageing and inflammation – A central role for mitochondria in brain health and disease

Highlights • Understanding neurodegenerative diseases in the context of ageing. • Differentiation leads to the accumulation of biological imperfections with ageing. • Inflammation as a response to age-associated stress involving all cells. • Metabolic changes regulated by mitochondria may confer protection or cause disease. • Relationship metabolism/differentiation/inflammation is essential to study disease.