Angiotensins as therapeutic targets beyond heart disease

Highlights • The RAS is a key regulator of cardiovascular and hydro-electrolyte homeostasis. • Novel actions and therapeutics implications of the RAS were recently identified. • Angiotensins are therapeutic targets beyond heart disease. • The role of angiotensins in diverse disorders is briefly revi...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2015-05, Vol.36 (5), p.310-320
Hauptverfasser:	Passos-Silva, Danielle Gomes, Brandan, Enrique, Santos, Robson Augusto Souza
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science angiotensin II angiotensin-(1–7) Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals cancer Erectile Dysfunction - drug therapy Erectile Dysfunction - metabolism Glaucoma - drug therapy Glaucoma - metabolism Heart Diseases - drug therapy Heart Diseases - metabolism Humans Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Male Mas receptor Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Renin-Angiotensin System
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Beschreibung
Zusammenfassung:	Highlights • The RAS is a key regulator of cardiovascular and hydro-electrolyte homeostasis. • Novel actions and therapeutics implications of the RAS were recently identified. • Angiotensins are therapeutic targets beyond heart disease. • The role of angiotensins in diverse disorders is briefly reviewed. • Activation of ACE2/Ang-(1–7)/Mas and/or inhibition of the classical ACE/Ang II/AT1R axis can be effective in many disorders.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2015.03.001