Simple Colorimetric Detection of Amyloid β-peptide (1-40) based on Aggregation of Gold Nanoparticles in the Presence of Copper Ions

A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid‐β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1–40) is 0.6 nm and the promising results from practical samples (huma...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-05, Vol.11 (18), p.2144-2149
Hauptverfasser:	Zhou, Yanli, Dong, Hui, Liu, Lantao, Xu, Maotian
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Alzheimer Disease - blood Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - analysis Amyloid beta-Peptides - blood amyloid β-peptide Biomarkers - analysis Biosensing Techniques - methods Cations, Divalent colorimetric sensor Colorimetry Colorimetry - methods Copper copper ion Gold gold nanoparticles Human Humans Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission Nanoparticles Peptide Fragments - analysis Peptide Fragments - blood Serums Spectrophotometry
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Beschreibung
Zusammenfassung:	A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid‐β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1–40) is 0.6 nm and the promising results from practical samples (human serum) indicate the great potential for the routine detection.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201402593