Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging
To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firef...
Gespeichert in:
| Veröffentlicht in: | Analytical chemistry (Washington) 2014-03, Vol.86 (5), p.2747-2751 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2751 |
|---|---|
| container_issue | 5 |
| container_start_page | 2747 |
| container_title | Analytical chemistry (Washington) |
| container_volume | 86 |
| creator | Li, Jing Chen, Laizhong Wu, Wenxiao Zhang, Wei Ma, Zhao Cheng, Yanna Du, Lupei Li, Minyong |
| description | To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase. To the best of our knowledge, they are the first bioluminescent probes for imaging APN in deep tissues and living animals. |
| doi_str_mv | 10.1021/ac404176x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1692321399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3245438611</sourcerecordid><originalsourceid>FETCH-LOGICAL-a442t-d5a8f84e74be0e16e1b53fe95c46058dc94f831c8d2ea5225ec92d1158a7775a3</originalsourceid><addsrcrecordid>eNqF0U1LwzAYB_AgipvTg19ACiLoofokTdrkJHO-DYZ60HNJ06ejo21msor79nZsDtGDpwfCj3-eF0KOKVxSYPRKGw6cJvHnDulTwSCMpWS7pA8AUcgSgB458H4GQCnQeJ_0GOcKlIr65Pq29MZ-oFsGtghuSlu1ddnYKTalCV6czdAHhXXBcPU6x_mizLXH4CkY13paNtNDslfoyuPRpg7I2_3d6-gxnDw_jEfDSag5Z4swF1oWkmPCMwSkMdJMRAUqYXgMQuZG8UJG1MicoRaMCTSK5ZQKqZMkEToakPN17tzZ9xb9Iq27xrGqdIO29SmNFYsYjbqh_qUCOBeMC9HR0190ZlvXdIOsVKyU4F3mgFyslXHWe4dFOndlrd0ypZCuDpBuD9DZk01im9WYb-X3xjtwtgba-B-__Qn6Aq35idk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506995421</pqid></control><display><type>article</type><title>Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging</title><source>MEDLINE</source><source>ACS Publications</source><creator>Li, Jing ; Chen, Laizhong ; Wu, Wenxiao ; Zhang, Wei ; Ma, Zhao ; Cheng, Yanna ; Du, Lupei ; Li, Minyong</creator><creatorcontrib>Li, Jing ; Chen, Laizhong ; Wu, Wenxiao ; Zhang, Wei ; Ma, Zhao ; Cheng, Yanna ; Du, Lupei ; Li, Minyong</creatorcontrib><description>To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase. To the best of our knowledge, they are the first bioluminescent probes for imaging APN in deep tissues and living animals.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac404176x</identifier><identifier>PMID: 24490993</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Analytical chemistry ; Bioluminescence ; Biomedical materials ; CD13 Antigens - metabolism ; Emission ; Enzyme kinetics ; Hydrolysis ; Imaging ; In vivo testing ; In vivo tests ; Insects ; Luminescence ; Molecular Probes ; Surgical implants ; Tissues</subject><ispartof>Analytical chemistry (Washington), 2014-03, Vol.86 (5), p.2747-2751</ispartof><rights>Copyright © 2014 American Chemical Society</rights><rights>Copyright American Chemical Society Mar 4, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a442t-d5a8f84e74be0e16e1b53fe95c46058dc94f831c8d2ea5225ec92d1158a7775a3</citedby><cites>FETCH-LOGICAL-a442t-d5a8f84e74be0e16e1b53fe95c46058dc94f831c8d2ea5225ec92d1158a7775a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac404176x$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac404176x$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24490993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Chen, Laizhong</creatorcontrib><creatorcontrib>Wu, Wenxiao</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Ma, Zhao</creatorcontrib><creatorcontrib>Cheng, Yanna</creatorcontrib><creatorcontrib>Du, Lupei</creatorcontrib><creatorcontrib>Li, Minyong</creatorcontrib><title>Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase. To the best of our knowledge, they are the first bioluminescent probes for imaging APN in deep tissues and living animals.</description><subject>Analytical chemistry</subject><subject>Bioluminescence</subject><subject>Biomedical materials</subject><subject>CD13 Antigens - metabolism</subject><subject>Emission</subject><subject>Enzyme kinetics</subject><subject>Hydrolysis</subject><subject>Imaging</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Insects</subject><subject>Luminescence</subject><subject>Molecular Probes</subject><subject>Surgical implants</subject><subject>Tissues</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LwzAYB_AgipvTg19ACiLoofokTdrkJHO-DYZ60HNJ06ejo21msor79nZsDtGDpwfCj3-eF0KOKVxSYPRKGw6cJvHnDulTwSCMpWS7pA8AUcgSgB458H4GQCnQeJ_0GOcKlIr65Pq29MZ-oFsGtghuSlu1ddnYKTalCV6czdAHhXXBcPU6x_mizLXH4CkY13paNtNDslfoyuPRpg7I2_3d6-gxnDw_jEfDSag5Z4swF1oWkmPCMwSkMdJMRAUqYXgMQuZG8UJG1MicoRaMCTSK5ZQKqZMkEToakPN17tzZ9xb9Iq27xrGqdIO29SmNFYsYjbqh_qUCOBeMC9HR0190ZlvXdIOsVKyU4F3mgFyslXHWe4dFOndlrd0ypZCuDpBuD9DZk01im9WYb-X3xjtwtgba-B-__Qn6Aq35idk</recordid><startdate>20140304</startdate><enddate>20140304</enddate><creator>Li, Jing</creator><creator>Chen, Laizhong</creator><creator>Wu, Wenxiao</creator><creator>Zhang, Wei</creator><creator>Ma, Zhao</creator><creator>Cheng, Yanna</creator><creator>Du, Lupei</creator><creator>Li, Minyong</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20140304</creationdate><title>Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging</title><author>Li, Jing ; Chen, Laizhong ; Wu, Wenxiao ; Zhang, Wei ; Ma, Zhao ; Cheng, Yanna ; Du, Lupei ; Li, Minyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a442t-d5a8f84e74be0e16e1b53fe95c46058dc94f831c8d2ea5225ec92d1158a7775a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analytical chemistry</topic><topic>Bioluminescence</topic><topic>Biomedical materials</topic><topic>CD13 Antigens - metabolism</topic><topic>Emission</topic><topic>Enzyme kinetics</topic><topic>Hydrolysis</topic><topic>Imaging</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>Insects</topic><topic>Luminescence</topic><topic>Molecular Probes</topic><topic>Surgical implants</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Chen, Laizhong</creatorcontrib><creatorcontrib>Wu, Wenxiao</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Ma, Zhao</creatorcontrib><creatorcontrib>Cheng, Yanna</creatorcontrib><creatorcontrib>Du, Lupei</creatorcontrib><creatorcontrib>Li, Minyong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jing</au><au>Chen, Laizhong</au><au>Wu, Wenxiao</au><au>Zhang, Wei</au><au>Ma, Zhao</au><au>Cheng, Yanna</au><au>Du, Lupei</au><au>Li, Minyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2014-03-04</date><risdate>2014</risdate><volume>86</volume><issue>5</issue><spage>2747</spage><epage>2751</epage><pages>2747-2751</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase. To the best of our knowledge, they are the first bioluminescent probes for imaging APN in deep tissues and living animals.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>24490993</pmid><doi>10.1021/ac404176x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 2014-03, Vol.86 (5), p.2747-2751 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1692321399 |
| source | MEDLINE; ACS Publications |
| subjects | Analytical chemistry Bioluminescence Biomedical materials CD13 Antigens - metabolism Emission Enzyme kinetics Hydrolysis Imaging In vivo testing In vivo tests Insects Luminescence Molecular Probes Surgical implants Tissues |
| title | Discovery of Bioluminogenic Probes for Aminopeptidase N Imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T14%3A14%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20Bioluminogenic%20Probes%20for%20Aminopeptidase%20N%20Imaging&rft.jtitle=Analytical%20chemistry%20(Washington)&rft.au=Li,%20Jing&rft.date=2014-03-04&rft.volume=86&rft.issue=5&rft.spage=2747&rft.epage=2751&rft.pages=2747-2751&rft.issn=0003-2700&rft.eissn=1520-6882&rft.coden=ANCHAM&rft_id=info:doi/10.1021/ac404176x&rft_dat=%3Cproquest_cross%3E3245438611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506995421&rft_id=info:pmid/24490993&rfr_iscdi=true |