Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
Lemoine et al provide a brief history of ligand-gated ion channels (LGICs), which function as a mediator in intercellular communication. They detail the contribution fo LGIC dysfunction to disease, and they note the thereapeutic use of LGIC in the treatment of various disesases.
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| Veröffentlicht in: | Chemical reviews 2012-12, Vol.112 (12), p.6285-6318 |
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| container_end_page | 6318 |
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| container_issue | 12 |
| container_start_page | 6285 |
| container_title | Chemical reviews |
| container_volume | 112 |
| creator | Lemoine, Damien Jiang, Ruotian Taly, Antoine Chataigneau, Thierry Specht, Alexandre Grutter, Thomas |
| description | Lemoine et al provide a brief history of ligand-gated ion channels (LGICs), which function as a mediator in intercellular communication. They detail the contribution fo LGIC dysfunction to disease, and they note the thereapeutic use of LGIC in the treatment of various disesases. |
| doi_str_mv | 10.1021/cr3000829 |
| format | Article |
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They detail the contribution fo LGIC dysfunction to disease, and they note the thereapeutic use of LGIC in the treatment of various disesases.</description><subject>Analytical chemistry</subject><subject>Animals</subject><subject>Disease</subject><subject>Disorders</subject><subject>Humans</subject><subject>Ion channels</subject><subject>Ions</subject><subject>Ligand-Gated Ion Channels - antagonists & inhibitors</subject><subject>Ligand-Gated Ion Channels - chemistry</subject><subject>Ligand-Gated Ion Channels - metabolism</subject><subject>Ligands</subject><subject>Medical services</subject><subject>Models, Molecular</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Nervous System Diseases - metabolism</subject><subject>Neurochemistry</subject><subject>Recognition</subject><issn>0009-2665</issn><issn>1520-6890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVJqZ20h_6BIAiF5LCtZuSVVrkF56MG00JpL70sWknrKKylRNql9N9Xxa4pzaGnYYaHZ2Z4CXkL7D0whA8mccZYg-oFmUONrBKNYkdkXoaqQiHqGTnO-aG0dY3yFZkhqqZRAufk-9pvdLDVnR6dpasY6PJeh-CGfEk_uR90FbLf3I-Z-jDGMplSHOLGGz3Qa59jsi5lWgR056FfnImb4Ecfw2vystdDdm_29YR8u735uvxYrT_frZZX60pzKcZKdqLvJVqNHcjOcoCOq0VXC9d0AKa2RiEHayUgsEb0XFumF2ikXJiag-Qn5HznfUzxaXJ5bLc-GzcMOrg45RZEEZTXEf6PLpQCjko2BT37B32IUwrlkRZQlGNqBlioix1lUsw5ub59TH6r088WWPs7m_aQTWFP98ap2zp7IP-EUYB3O0Cb_Ne2Z6Jf8aaScg</recordid><startdate>20121212</startdate><enddate>20121212</enddate><creator>Lemoine, Damien</creator><creator>Jiang, Ruotian</creator><creator>Taly, Antoine</creator><creator>Chataigneau, Thierry</creator><creator>Specht, Alexandre</creator><creator>Grutter, Thomas</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20121212</creationdate><title>Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition</title><author>Lemoine, Damien ; Jiang, Ruotian ; Taly, Antoine ; Chataigneau, Thierry ; Specht, Alexandre ; Grutter, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-7b6ff72da2b17bd311b394b56e8b11c5dc9231dd7121086f3ad0a42c774c53173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analytical chemistry</topic><topic>Animals</topic><topic>Disease</topic><topic>Disorders</topic><topic>Humans</topic><topic>Ion channels</topic><topic>Ions</topic><topic>Ligand-Gated Ion Channels - antagonists & inhibitors</topic><topic>Ligand-Gated Ion Channels - chemistry</topic><topic>Ligand-Gated Ion Channels - metabolism</topic><topic>Ligands</topic><topic>Medical services</topic><topic>Models, Molecular</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Nervous System Diseases - metabolism</topic><topic>Neurochemistry</topic><topic>Recognition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemoine, Damien</creatorcontrib><creatorcontrib>Jiang, Ruotian</creatorcontrib><creatorcontrib>Taly, Antoine</creatorcontrib><creatorcontrib>Chataigneau, Thierry</creatorcontrib><creatorcontrib>Specht, Alexandre</creatorcontrib><creatorcontrib>Grutter, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemoine, Damien</au><au>Jiang, Ruotian</au><au>Taly, Antoine</au><au>Chataigneau, Thierry</au><au>Specht, Alexandre</au><au>Grutter, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition</atitle><jtitle>Chemical reviews</jtitle><addtitle>Chem. 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| fulltext | fulltext |
| identifier | ISSN: 0009-2665 |
| ispartof | Chemical reviews, 2012-12, Vol.112 (12), p.6285-6318 |
| issn | 0009-2665 1520-6890 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Analytical chemistry Animals Disease Disorders Humans Ion channels Ions Ligand-Gated Ion Channels - antagonists & inhibitors Ligand-Gated Ion Channels - chemistry Ligand-Gated Ion Channels - metabolism Ligands Medical services Models, Molecular Nervous System Diseases - drug therapy Nervous System Diseases - metabolism Neurochemistry Recognition |
| title | Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition |
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