Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition

Lemoine et al provide a brief history of ligand-gated ion channels (LGICs), which function as a mediator in intercellular communication. They detail the contribution fo LGIC dysfunction to disease, and they note the thereapeutic use of LGIC in the treatment of various disesases.

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Veröffentlicht in:	Chemical reviews 2012-12, Vol.112 (12), p.6285-6318
Hauptverfasser:	Lemoine, Damien, Jiang, Ruotian, Taly, Antoine, Chataigneau, Thierry, Specht, Alexandre, Grutter, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Disease Disorders Humans Ion channels Ions Ligand-Gated Ion Channels - antagonists & inhibitors Ligand-Gated Ion Channels - chemistry Ligand-Gated Ion Channels - metabolism Ligands Medical services Models, Molecular Nervous System Diseases - drug therapy Nervous System Diseases - metabolism Neurochemistry Recognition
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Beschreibung
Zusammenfassung:	Lemoine et al provide a brief history of ligand-gated ion channels (LGICs), which function as a mediator in intercellular communication. They detail the contribution fo LGIC dysfunction to disease, and they note the thereapeutic use of LGIC in the treatment of various disesases.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr3000829