Cinachyrolide A : a potent cytotoxic macrolide possessing two spiro ketals from marine sponge Cinachyra sp

Cinachyrolide A : a potent cytotoxic macrolide possessing two spiro ketals from marine sponge Cinachyra sp

A highly cytotoxic macrolide, cinachyrolide A, has been isolated from marine sponge Cinachyra sp. The gross structure was determined mainly by extensive 2D NMR experiments. The relative stereochemistry of the six oxane rings is proposed on the basis of NOESY data.

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Veröffentlicht in:Journal of the American Chemical Society 1993-05, Vol.115 (10), p.3977-3981
Hauptverfasser: FUSETANI, N, SHINODA, K, MATSUNAGA, S
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cinachyra
General pharmacology
Marine
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Zusammenfassung:A highly cytotoxic macrolide, cinachyrolide A, has been isolated from marine sponge Cinachyra sp. The gross structure was determined mainly by extensive 2D NMR experiments. The relative stereochemistry of the six oxane rings is proposed on the basis of NOESY data.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00063a017