Serum Human Trefoil Factor 3 is a Biomarker for Mucosal Healing in Ulcerative Colitis Patients with Minimal Disease Activity

Background: The goals of treating ulcerative colitis (UC) have shifted from clinical remission to mucosal healing. Non-invasive biomarkers are required to assess mucosal healing as endoscopic assessment is inconvenient for patients. Enhanced expression of trefoil factor 3 (TFF3, a mucin-associated p...

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Veröffentlicht in:	Journal of Crohn's and colitis 2015-07, Vol.9 (7), p.575-579
Hauptverfasser:	Srivastava, Saurabh, Kedia, Saurabh, Kumar, Sushil, Pratap Mouli, Venigalla, Dhingra, Rajan, Sachdev, Vikas, Tiwari, Veena, Kurrey, Lalit, Pradhan, Rajesh, Ahuja, Vineet
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Biomarkers - blood Colitis, Ulcerative - blood Colitis, Ulcerative - pathology Colonoscopy Cross-Sectional Studies Female Humans Intestinal Mucosa - physiology Male Middle Aged Peptides - blood Predictive Value of Tests ROC Curve Severity of Illness Index Trefoil Factor-3 Wound Healing
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Zusammenfassung:	Background: The goals of treating ulcerative colitis (UC) have shifted from clinical remission to mucosal healing. Non-invasive biomarkers are required to assess mucosal healing as endoscopic assessment is inconvenient for patients. Enhanced expression of trefoil factor 3 (TFF3, a mucin-associated peptide) is observed after injury of the gastrointestinal tract. The present study was designed to evaluate TFF3 as a biomarker of mucosal healing in patients with UC. Methods: This cross-sectional study included consecutive patients with UC (18–65 years old, disease duration >3 months, either left-sided colitis or pancolitis) who had a Simple Clinical Colitis Activity Index (SCCAI)
ISSN:	1873-9946 1876-4479
DOI:	10.1093/ecco-jcc/jjv075