An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B

Background & Aims Differences in intrahepatic gene expression patterns may be associated with therapy response in peginterferon‐treated chronic hepatitis B (CHB) patients. Methods We employed gene expression profiling in baseline liver biopsies of 40 CHB patients (19 HBeAg‐positive; 21 HBeAg‐neg...

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Veröffentlicht in:Liver international 2015-07, Vol.35 (7), p.1824-1832
Hauptverfasser: Jansen, Louis, de Niet, Annikki, Makowska, Zuzanna, Dill, Michael T., van Dort, Karel A., Terpstra, Valeska, Bart Takkenberg, R., Janssen, Harry L.A., Heim, Markus H., Kootstra, Neeltje A., Reesink, Hendrik W.
Format: Artikel
Sprache:eng
Schlagworte:
adefovir
Adenine - analogs & derivatives
Adenine - therapeutic use
Adult
Antiviral Agents - therapeutic use
Biopsy
Chi-Square Distribution
chronic hepatitis B
combined response
Drug Therapy, Combination
Female
gene expression
Gene Expression Profiling - methods
Genetic Markers
Hepatitis B, Chronic - diagnosis
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - immunology
Humans
Interferon-alpha - therapeutic use
Liver - drug effects
Liver - immunology
Liver - metabolism
Liver - virology
liver biopsy
Logistic Models
Male
microarray
Middle Aged
Multivariate Analysis
Oligonucleotide Array Sequence Analysis
Organophosphonates - therapeutic use
Patient Selection
peginterferon alfa-2a
Polyethylene Glycols - therapeutic use
Precision Medicine
Predictive Value of Tests
Recombinant Proteins - therapeutic use
Reproducibility of Results
response marker
Time Factors
Treatment Outcome
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Zusammenfassung:Background & Aims Differences in intrahepatic gene expression patterns may be associated with therapy response in peginterferon‐treated chronic hepatitis B (CHB) patients. Methods We employed gene expression profiling in baseline liver biopsies of 40 CHB patients (19 HBeAg‐positive; 21 HBeAg‐negative) treated with peginterferon and adefovir for 48 weeks, and compared expression patterns of combined responders (HBeAg loss, HBV‐DNA
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.12768