Non-immunoglobulin scaffolds: a focus on their targets

Non-immunoglobulin scaffolds: a focus on their targets

Highlights • Non-immunoglobulin (non-Ig) scaffolds are small antibody alternatives. • 139 binders of 20 different non-Ig scaffold types have been developed against 102 different targets. • Their main application is in the treatment and diagnosis of cancer and inflammatory diseases. • They can also b...

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Veröffentlicht in:Trends in biotechnology (Regular ed.) 2015-07, Vol.33 (7), p.408-418
Hauptverfasser: Škrlec, Katja, Štrukelj, Borut, Berlec, Aleš
Format: Artikel
Sprache:eng
Schlagworte:
Animals
antibody alternatives
Binders
Cancer therapies
Clinical trials
Cytokines
Deoxyribonucleic acid
Disease
DNA
Drug Delivery Systems
Enzymes
Epidermal growth factor
Humans
Immunoglobulins
Internal Medicine
Kinases
Lymphocyte receptors
Molecular weight
non-immunoglobulin scaffolds
Proteins
Recombinant Proteins
Single-Domain Antibodies
Tumors
Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:Highlights • Non-immunoglobulin (non-Ig) scaffolds are small antibody alternatives. • 139 binders of 20 different non-Ig scaffold types have been developed against 102 different targets. • Their main application is in the treatment and diagnosis of cancer and inflammatory diseases. • They can also be used in structural studies and post-translational modification monitoring.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2015.03.012