Airway hyper-responsiveness to mannitol provides a good evaluation of atopy in childhood asthma

Airway hyper-responsiveness to mannitol provides a good evaluation of atopy in childhood asthma

Aim The relationship between airway hyper‐responsiveness (AHR) and atopy has been previously investigated, but there are still some issues to be clarified. The aim of this study was to assess the link between AHR and mannitol and atopy in asthmatic children. Methods We evaluated 44 children with ast...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Paediatrica 2015-07, Vol.104 (7), p.718-723
Hauptverfasser: Attanasi, M, Rapino, D, Marcovecchio, M L, Consilvio, N P, Scaparrotta, A, Cingolani, A, Di Pillo, S, Chiarelli, F
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Airway hyper-responsiveness
Allergens - immunology
Asthma
Asthma - blood
Asthma - diagnosis
Asthma - physiopathology
Atopy
Bronchial Hyperreactivity - blood
Bronchial Hyperreactivity - chemically induced
Bronchial Provocation Tests
Child
Children
Cohort Studies
Female
Humans
Immunoglobulin E - blood
Male
Mannitol
Severity of Illness Index
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim The relationship between airway hyper‐responsiveness (AHR) and atopy has been previously investigated, but there are still some issues to be clarified. The aim of this study was to assess the link between AHR and mannitol and atopy in asthmatic children. Methods We evaluated 44 children with asthma, aged 6–16 years of age, using skin prick tests (SPTs), serum total and specific immunoglobulin E (IgE) levels and the mannitol challenge test (MCT). Results We found a good correlation between AHR to mannitol and specific IgE against Dermatophagoides pteronissinus (r = −0.66, p 
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.12968