Circular RNAs remain peculiarly unclear in biogenesis and function

The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the ＂common＂ linear form, these molecules were first described in 1976, when it was discov- ered that s...

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Veröffentlicht in:	Science China. Life sciences 2015-06, Vol.58 (6), p.616-618
Hauptverfasser:	Chen, Liang, Shan, Ge
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Biomedical and Life Sciences Caenorhabditis elegans Cell Nucleus - metabolism Cytoplasm - metabolism Drosophila Genome-Wide Association Study Humans Insight Life Sciences Mice Models, Genetic Ribonucleoprotein, U1 Small Nuclear - metabolism RNA RNA - biosynthesis RNA - genetics RNA - physiology 圆形复杂性家族生物合成类病毒线性形式转录
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Beschreibung
Zusammenfassung:	The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the ＂common＂ linear form, these molecules were first described in 1976, when it was discov- ered that several plant viroids were single-stranded and co- valently closed circular RNAs [4].
ISSN:	1674-7305 1869-1889
DOI:	10.1007/s11427-015-4855-y