A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability

A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2](2+) (bpy = 2,2'-bipyridine, L1 = 4,4'-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can only be activated...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (53), p.10684-10686
Hauptverfasser:	Zhou, Qian-Xiong, Zheng, Yue, Wang, Tian-Ji, Chen, Yong-Jie, Li, Ke, Zhang, Yang-Yang, Li, Chao, Hou, Yuan-Jun, Wang, Xue-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - chemistry Coordination Complexes - chemistry DNA - chemistry Glutathione - chemistry Light Oxidation-Reduction Quantum Theory Ruthenium - chemistry
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Beschreibung
Zusammenfassung:	A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2](2+) (bpy = 2,2'-bipyridine, L1 = 4,4'-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can only be activated after GSH reduction and visible light irradiation.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc03291a