Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants

Background: Activated leukocytes and infection are implicated in neonatal brain injury. Leukocyte surface receptors are increased in stroke models and may be targets for future adjunctive therapies. Methods: Serial blood samples were analyzed from preterm infants ( n = 51;

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Bibliographische Detailangaben
Veröffentlicht in:	Pediatric research 2015-07, Vol.78 (1), p.82-90
Hauptverfasser:	O’Hare, Fiona M., Watson, William, O’Neill, Amanda, Grant, Tim, Onwuneme, Chike, Donoghue, Veronica, Mooney, Eoghan, Downey, Paul, Murphy, John, Twomey, Anne, Molloy, Eleanor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 Adult Brain Injuries - blood CD11b Antigen - blood Cell Membrane - metabolism clinical-investigation Female Flow Cytometry Gene Expression Regulation Humans Infant, Newborn Infant, Premature Lipopolysaccharides - chemistry Magnetic Resonance Imaging Male Medicine & Public Health Monocytes - cytology Neuroimaging Neutrophils - cytology Oxygen - metabolism Pediatric Surgery Pediatrics Reactive Oxygen Species - metabolism Toll-Like Receptor 4 - blood
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Beschreibung
Zusammenfassung:	Background: Activated leukocytes and infection are implicated in neonatal brain injury. Leukocyte surface receptors are increased in stroke models and may be targets for future adjunctive therapies. Methods: Serial blood samples were analyzed from preterm infants ( n = 51;
ISSN:	0031-3998 1530-0447
DOI:	10.1038/pr.2015.66