The immunomodulating effect of seminal plasma on T cells

Highlights • We investigated the direct effect and indirect APC-mediated effect of SP on T cells. • SP has a direct proliferative effect on T cells and several markers are increased. • APCs are needed to induce expression of IL-10 and CD25 in T cells exposed to SP. • Expression of IL-10 and CD25 sug...

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Veröffentlicht in:	Journal of reproductive immunology 2015-08, Vol.110, p.109-116
Hauptverfasser:	Meuleman, T, Snaterse, G, van Beelen, E, Anholts, J.D.H, Pilgram, G.S.K, van der Westerlaken, L.A.J, Eikmans, M, Claas, F.H.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult APCs CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology Cell Proliferation Female HLA Antigens - immunology Humans Immunomodulation Interleukin-10 - immunology Interleukin-2 Receptor alpha Subunit - immunology Male Obstetrics and Gynecology PBMCs Semen - immunology Seminal plasma T cells Up-Regulation - immunology
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Beschreibung
Zusammenfassung:	Highlights • We investigated the direct effect and indirect APC-mediated effect of SP on T cells. • SP has a direct proliferative effect on T cells and several markers are increased. • APCs are needed to induce expression of IL-10 and CD25 in T cells exposed to SP. • Expression of IL-10 and CD25 suggests the induction of a immunoregulatory response.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.01.012