Microgonotropens and their interactions with DNA. 1. Synthesis of the tripyrrole peptides dien-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA

Microgonotropens and their interactions with DNA. 1. Synthesis of the tripyrrole peptides dien-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA

Exploration of the novel idea to employ a pyrrole nitrogen of a tripyrrole peptide minor groove binding agent to carry catalytic entities to the phosphates and major groove of DNA has been initiated with the synthesis of dien-microgonotropen-a, -b, and -c.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 1993-08, Vol.115 (16), p.7061-7071
Hauptverfasser: He, Gong-Xin, Browne, KA, Groppe, J C, Blasko, A, Mei, Houng-Yau, Bruice, T C
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Exploration of the novel idea to employ a pyrrole nitrogen of a tripyrrole peptide minor groove binding agent to carry catalytic entities to the phosphates and major groove of DNA has been initiated with the synthesis of dien-microgonotropen-a, -b, and -c.
ISSN:0002-7863
DOI:10.1021/ja00069a002