Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction

Catalytic Enantioselective Synthesis of Planar-Chiral Cyclic Amides Based on a Pd-Catalyzed Asymmetric Allylic Substitution Reaction

The highly enantioselective synthesis of planar-chiral nine-membered cyclic amides was achieved by the Pd-catalyzed asymmetric allylic cyclization of achiral linear precursors in the presence of a catalytic amount of chiral ligand.

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Veröffentlicht in:Journal of the American Chemical Society 2015-06, Vol.137 (23), p.7294-7297
Hauptverfasser: Igawa, Kazunobu, Ichikawa, Nobumasa, Ano, Yusuke, Katanoda, Keisuke, Ito, Masato, Akiyama, Toshiyuki, Tomooka, Katsuhiko
Format: Artikel
Sprache:eng
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Zusammenfassung:The highly enantioselective synthesis of planar-chiral nine-membered cyclic amides was achieved by the Pd-catalyzed asymmetric allylic cyclization of achiral linear precursors in the presence of a catalytic amount of chiral ligand.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b04340