Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients

Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum l...

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Veröffentlicht in:Archives of Dermatological Research 2015-07, Vol.307 (5), p.455-459
Hauptverfasser: Zhang, C., Zhu, K. J., Liu, J. L., Xu, G. X., Liu, W., Jiang, F. X., Zheng, H. F., Quan, C.
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Sprache:eng
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Zusammenfassung:Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay. The expressions of omentin-1 were measured by immunohistochemistry in 3 psoriasis affected skins and 3 normal skins. The rs2274907 variant was typed using a SNaPshot assay in 354 cases and 214 controls. We found significantly lower serum levels of omentin-1 in psoriasis patients compared with healthy controls ( p  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-015-1549-z