Association Between Perioperative Dexmedetomidine and Arrhythmias After Surgery for Congenital Heart Disease

Association Between Perioperative Dexmedetomidine and Arrhythmias After Surgery for Congenital Heart Disease

BACKGROUND—Dexmedetomidine is commonly used after congenital heart surgery and may be associated with a decreased incidence of postoperative tachyarrhythmias. Using a large cohort of patients undergoing congenital heart surgery, we examined for an association between dexmedetomidine use in the immed...

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Veröffentlicht in:Circulation. Arrhythmia and electrophysiology 2015-06, Vol.8 (3), p.643-650
Hauptverfasser: Shuplock, Jacqueline M, Smith, Andrew H, Owen, Jill, Van Driest, Sara L, Marshall, Matt, Saville, Benjamin, Xu, Meng, Radbill, Andrew E, Fish, Frank A, Kannankeril, Prince J
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic alpha-2 Receptor Agonists - adverse effects
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - diagnosis
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - physiopathology
Bradycardia - chemically induced
Bradycardia - epidemiology
Cardiac Surgical Procedures
Chi-Square Distribution
Child
Child, Preschool
Dexmedetomidine - adverse effects
Female
Heart Defects, Congenital - surgery
Humans
Incidence
Infant
Infant, Newborn
Logistic Models
Male
Multivariate Analysis
Odds Ratio
Propensity Score
Retrospective Studies
Risk Factors
Tachycardia - chemically induced
Tachycardia - epidemiology
Tennessee - epidemiology
Time Factors
Treatment Outcome
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Zusammenfassung:BACKGROUND—Dexmedetomidine is commonly used after congenital heart surgery and may be associated with a decreased incidence of postoperative tachyarrhythmias. Using a large cohort of patients undergoing congenital heart surgery, we examined for an association between dexmedetomidine use in the immediate postoperative period and subsequent arrhythmia development. METHODS AND RESULTS—A total of 1593 surgical procedures for congenital heart disease were performed. Dexmedetomidine was administered in the immediate postoperative period after 468 (29%) surgical procedures. When compared with 1125 controls, the group receiving dexmedetomidine demonstrated significantly fewer tachyarrhythmias (29% versus 38%; P
ISSN:1941-3149
1941-3084
DOI:10.1161/CIRCEP.114.002301