Temozolomide-loaded photopolymerizable PEG-DMA-based hydrogel for the treatment of glioblastoma

Glioblastoma is the most frequent primary malignant brain tumor in adults. Despite treatments including surgery, radiotherapy and chemotherapy by oral Temozolomide (TMZ), the prognosis of patients with glioblastoma remains very poor. We hypothesized that a polyethylene glycol dimethacrylate (PEG-DMA...

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Veröffentlicht in:	Journal of controlled release 2015-07, Vol.210, p.95-104
Hauptverfasser:	Fourniols, Thibaut, Randolph, Luc D., Staub, Aurélie, Vanvarenberg, Kevin, Leprince, Julian G., Préat, Véronique, des Rieux, Anne, Danhier, Fabienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - radiation effects Antineoplastic Agents, Alkylating - therapeutic use Apoptosis - drug effects Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Dacarbazine - chemistry Dacarbazine - radiation effects Dacarbazine - therapeutic use Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - radiation effects Delayed-Action Preparations - therapeutic use Drug Delivery Systems Female Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Humans Hydrogels - administration & dosage Hydrogels - chemistry Hydrogels - radiation effects Hydrogels - therapeutic use Light Methacrylates - chemistry Methacrylates - radiation effects Mice, Nude Microglia - drug effects PEG-DMA Photopolymerizable hydrogel Polyethylene Glycols - chemistry Polyethylene Glycols - radiation effects Polymeric micelles Temozolomide Tumor Burden - drug effects
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Zusammenfassung:	Glioblastoma is the most frequent primary malignant brain tumor in adults. Despite treatments including surgery, radiotherapy and chemotherapy by oral Temozolomide (TMZ), the prognosis of patients with glioblastoma remains very poor. We hypothesized that a polyethylene glycol dimethacrylate (PEG-DMA) injectable hydrogel would provide a sustained and local delivery of TMZ. The hydrogel photopolymerized rapidly (
ISSN:	0168-3659 1873-4995
DOI:	10.1016/j.jconrel.2015.05.272