Mid‐regional pro‐atrial natriuretic peptide and the assessment of volaemic status and differential diagnosis of profound hyponatraemia

Background Hyponatraemia is common and its differential diagnosis and consequent therapy management is challenging. The differential diagnosis is mainly based on the routine clinical assessment of volume status, which is often misleading. Mid‐regional pro‐atrial natriuretic peptide (MR‐proANP) is as...

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Veröffentlicht in:	Journal of internal medicine 2015-07, Vol.278 (1), p.29-37
Hauptverfasser:	Nigro, N., Winzeler, B., Suter‐Widmer, I., Schuetz, P., Arici, B., Bally, M., Blum, C. A., Nickel, C. H., Bingisser, R., Bock, A., Rentsch Savoca, K., Huber, A., Müller, B., Christ‐Crain, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Atrial Natriuretic Factor - blood Biomarkers - blood Blood Volume Diagnosis, Differential Extracellular Fluid - metabolism Female Heart Failure - blood Heart Failure - complications Humans Hyponatremia - diagnosis Hyponatremia - etiology Hyponatremia - metabolism Male Middle Aged mid‐regional pro‐atrial natriuretic peptide Natriuretic Peptide, Brain - blood profound hyponatraemia Prospective Studies volume status
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Zusammenfassung:	Background Hyponatraemia is common and its differential diagnosis and consequent therapy management is challenging. The differential diagnosis is mainly based on the routine clinical assessment of volume status, which is often misleading. Mid‐regional pro‐atrial natriuretic peptide (MR‐proANP) is associated with extracellular and cardiac fluid volume. Methods A total of 227 consecutive patients admitted to the emergency department with profound hypo‐osmolar hyponatraemia (Na
ISSN:	0954-6820 1365-2796
DOI:	10.1111/joim.12332