Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway

Highlights • The role of LRRFIP1 in the EMT and invasion of carcinoma cells was investigated. • Repression of LRRFIP1 caused reversal of EMT and inhibited migration and invasion. • Silencing of LRRFIP1 regulated phosphorylation and nuclear localization of β-catenin. • β-catenin expressed on the memb...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2015-08, Vol.365 (1), p.132-140
Hauptverfasser:	Douchi, Daisuke, Ohtsuka, Hideo, Ariake, Kyohei, Masuda, Kunihiro, Kawasaki, Shuhei, Kawaguchi, Kei, Fukase, Koji, Oikawa, Masaya, Motoi, Fuyuhiko, Naitoh, Takeshi, Katayose, Yu, Egawa, Shinichi, Unno, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus beta Catenin - metabolism Cadherins - genetics Cadherins - metabolism Cell Line, Tumor Cell Movement Cell Proliferation EMT Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans LRRFIP1 Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Neoplasm Invasiveness Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphorylation Promoter Regions, Genetic Reverse EMT RNA Interference RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Transfection Wnt Signaling Pathway Wnt/β-catenin signaling β-catenin destruction complex
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The role of LRRFIP1 in the EMT and invasion of carcinoma cells was investigated. • Repression of LRRFIP1 caused reversal of EMT and inhibited migration and invasion. • Silencing of LRRFIP1 regulated phosphorylation and nuclear localization of β-catenin. • β-catenin expressed on the membrane was increased in LRRFIP1 silenced cancer cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.05.023