Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver

Highlights • Bile acid binding resin improved hepatic insulin sensitivity by reducing cholesterol but not triglyceride in the liver. • Fatty liver shionogi mice developed hepatic fat accumulation without dietary intervention. • Bile acid binding resin improved glycemic controls in the patients with...

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Veröffentlicht in:	Diabetes research and clinical practice 2015-07, Vol.109 (1), p.85-94
Hauptverfasser:	Tagawa, Hirotsune, Irie, Junichiro, Itoh, Arata, Kusumoto, Yukie, Kato, Mari, Kobayashi, Nana, Tanaka, Kumiko, Morinaga, Rieko, Fujita, Masataka, Nakajima, Yuya, Morimoto, Kohkichi, Sugizaki, Taichi, Kawano, Yoshinaga, Yamada, Satoru, Kawai, Toshihide, Watanabe, Mitsuhiro, Itoh, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile acid binding resin Bile Acids and Salts - administration & dosage Bile Acids and Salts - therapeutic use Blood Glucose - metabolism Cholesterol - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Endocrinology & Metabolism Fatty Liver - drug therapy Fatty Liver - metabolism Female Hepatic insulin resistance Humans Insulin Resistance Liver - drug effects Liver - metabolism Liver X Receptors Male Mice Mice, Inbred Strains Middle Aged Non-alcoholic fatty liver disease Orphan Nuclear Receptors - agonists Retrospective Studies Triglycerides - blood
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Zusammenfassung:	Highlights • Bile acid binding resin improved hepatic insulin sensitivity by reducing cholesterol but not triglyceride in the liver. • Fatty liver shionogi mice developed hepatic fat accumulation without dietary intervention. • Bile acid binding resin improved glycemic controls in the patients with type 2 diabetes without reducing fat mass.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.04.025