Effects of interleukin-6 on the bio-electric activity of rat atrial tissue under normal conditions and during gradual stretching

Highlights • Mechano-gated channels play critical role in the IL-6 induced myocardial dysfunction. • High IL-6 levels are exclusively connected with the atrial fibrillation. • IL-6 enhances the occurrence of atrial fibrillation induced by stretch. • IL-6 plays the role of initiator of the STAT phosp...

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Veröffentlicht in:	Immunobiology (1979) 2015-09, Vol.220 (9), p.1107-1112
Hauptverfasser:	Mitrokhin, V.M, Mladenov, M.I, Kamkin, A.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - physiology Advanced Basic Science Allergy and Immunology Animals Atrial Fibrillation - physiopathology Atrial Function - drug effects Atrium Electric Conductivity Gadolinium - pharmacology Heart Heart Atria - drug effects Interleukin-6 Interleukin-6 - pharmacology Male Microelectrodes Myocardial Contraction - physiology Perfusion Rats Rats, Wistar Stretch
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Beschreibung
Zusammenfassung:	Highlights • Mechano-gated channels play critical role in the IL-6 induced myocardial dysfunction. • High IL-6 levels are exclusively connected with the atrial fibrillation. • IL-6 enhances the occurrence of atrial fibrillation induced by stretch. • IL-6 plays the role of initiator of the STAT phosphorylation as a basic mechanism involved in the MGCs regulation.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2015.05.003