A Case of Acute Dapsone Poisoning: Toxicological Data and Review of the Literature

A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical features were dyspnea and deep cyanosis. Methemoglobinemia was 39.0% on admission. DDS was identified and quantitated in blood samples taken on the...

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Veröffentlicht in:	Journal of analytical toxicology 1995-07, Vol.19 (4), p.229-235
Hauptverfasser:	Tracqui, A., Gutbub, A.M., Kintz, P., Mangin, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Cyanosis - chemically induced dapsone Dapsone - blood Dapsone - poisoning Data processing Drug intoxications. Doping Dyspnea Dyspnea - chemically induced Female Hospitals Humans Leprostatic Agents - blood Leprostatic Agents - poisoning Literature reviews Medical sciences Methemoglobinemia Middle Aged Pharmacology. Drug treatments Poisoning Respiration
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Zusammenfassung:	A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical features were dyspnea and deep cyanosis. Methemoglobinemia was 39.0% on admission. DDS was identified and quantitated in blood samples taken on the third day (sample A) and fifth day (sample B) in the hospital using a high-performance liquid chromatographic technique with diode-array detection. DDS concentrations were 26.99 and 8.40 µg/mL in samples A and B, respectively. Results are discussed in the light of an extensive review of the literature (1950–1993) available on DDS poisonings.
ISSN:	0146-4760 1945-2403
DOI:	10.1093/jat/19.4.229