Initial suboptimal CD4 reconstitution with antiretroviral therapy despite full viral suppression in a cohort of HIV-infected patients in Senegal

We determined the risk factors and incidence of clinical events associated with suboptimal immune reconstitution (SIR) defined by an increase in CD4 inferior to 50cells/μL, from inclusion up to six months of antiretroviral treatment (ARVT), in patients with an undetectable viral load (

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Veröffentlicht in:	Médecine et maladies infectieuses 2015-06, Vol.45 (6), p.199-206
Hauptverfasser:	Batista, G., Buvé, A., Ngom Gueye, N.F., Manga, N.M., Diop, M.N., Ndiaye, K., Thiam, A., Ly, F., Diallo, A., Ndour, C.T., Seydi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Africa Afrique AIDS-Related Opportunistic Infections - epidemiology Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antiretroviral therapy Antiretroviral Therapy, Highly Active CD4 CD4 Lymphocyte Count Cohort Studies Comorbidity Female Follow-Up Studies HIV Infections - blood HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - immunology HIV-1 Humans Incidence Male Malnutrition - epidemiology Marriage Middle Aged Prognosis RIS Risk Factors Senegal - epidemiology SIR Traitement antirétroviral Treatment Outcome Viral Load Viremia - blood Viremia - drug therapy Viremia - epidemiology Viremia - immunology
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Zusammenfassung:	We determined the risk factors and incidence of clinical events associated with suboptimal immune reconstitution (SIR) defined by an increase in CD4 inferior to 50cells/μL, from inclusion up to six months of antiretroviral treatment (ARVT), in patients with an undetectable viral load (
ISSN:	0399-077X 1769-6690
DOI:	10.1016/j.medmal.2015.03.009