Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

A short review of biophysical mechanisms for electrotransfer of biaoctive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European biophysics journal 2015-07, Vol.44 (5), p.277-289
Hauptverfasser:	Venslauskas, Mindaugas S., Šatkauskas, Saulius
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological activity Biological and Medical Physics Biomedical and Life Sciences Biophysics Cell Biology Cell Membrane - chemistry Cell Membrane - metabolism Cell Membrane Permeability Cellular biology Electroporation Humans Life Sciences Membrane Biology Membranes Nanotechnology Neurobiology Organic Chemicals - pharmacokinetics Review
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A short review of biophysical mechanisms for electrotransfer of biaoctive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.
ISSN:	0175-7571 1432-1017
DOI:	10.1007/s00249-015-1025-x