Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment

Background The following review is a compilation of the recent advances and knowledge on the behaviour of the most frequently used compounds to treat inflammatory bowel disease in an organism. Results It considers clinical aspects of each entity and the pharmacokinetic/pharmacodynamic relationship s...

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Veröffentlicht in:	European journal of clinical pharmacology 2015-07, Vol.71 (7), p.773-799
Hauptverfasser:	Quetglas, E. G., Armuzzi, A., Wigge, S., Fiorino, G., Barnscheid, L., Froelich, M., Danese, Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Colitis, Ulcerative - diagnosis Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Crohn Disease - diagnosis Crohn Disease - drug therapy Crohn Disease - immunology Crohn's disease Drug Monitoring Gastrointestinal Agents - adverse effects Gastrointestinal Agents - pharmacokinetics Gastrointestinal Agents - therapeutic use Humans Inflammatory bowel disease Kinetics Pharmacogenetics Pharmacology Pharmacology/Toxicology Remission Induction Review Article Treatment Outcome
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Zusammenfassung:	Background The following review is a compilation of the recent advances and knowledge on the behaviour of the most frequently used compounds to treat inflammatory bowel disease in an organism. Results It considers clinical aspects of each entity and the pharmacokinetic/pharmacodynamic relationship supported by the use of plasma monitoring, tissue concentrations, and certain aspects derived from pharmacogenetics.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/s00228-015-1862-7