Can therapeutic hypothermia trigger propofol-related infusion syndrome?

Some risk factors are associated with PRIS, namely, higher propofol dosages (>4 mg/kg per hour), prolonged application (>48 hours), patients with neurologic or neurosurgical diseases, young age, exogenous catecholamine or glucocorticoid administration, inadequate carbohydrate intake, and subclinical mitochondrial disease [1,4-9]. [...]the use of vasopressor medications likely helped increase the blood concentration of propofol given their side effect of splanchnic vasoconstriction decreasing hepatic blood flow, thereby decreasing the clearance of propofol.