Special delivery: microparticles convey heme

In this issue of Blood, Camus et al describe how microparticles derived from sickle erythrocytes can deliver heme to vascular endothelial cells, leading to their activation and injury, and promote vasoocclusion in sickle cell disease (SCD).

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Bibliographische Detailangaben
Veröffentlicht in:	Blood 2015-06, Vol.125 (24), p.3677-3678
1. Verfasser:	Vercellotti, Gregory M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - complications Animals Cell-Derived Microparticles - pathology Endothelial Cells - pathology Heme - metabolism Humans Male Vascular Diseases - etiology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In this issue of Blood, Camus et al describe how microparticles derived from sickle erythrocytes can deliver heme to vascular endothelial cells, leading to their activation and injury, and promote vasoocclusion in sickle cell disease (SCD).
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood-2015-04-639484