Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate
•The administration of a Taenia hydatigena larvae vesicular concentrate (ThLVC) reduced the implantation of H. contortus larvae in lambs.•ThLVC-induced protection is associated to the expression of certain types of cytokines.•The ThLVC is a non-specific immune stimulator for the abomasal immune resp...
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| Veröffentlicht in: | Veterinary parasitology 2015-06, Vol.211 (1-2), p.60-66 |
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| creator | Buendía-Jiménez, J.A. Muñoz-Guzmán, M.A. Vega-López, M.A. Cuenca-Verde, C. Martínez-Labat, J.P. Cuéllar-Ordaz, J.A. Alba-Hurtado, F. |
| description | •The administration of a Taenia hydatigena larvae vesicular concentrate (ThLVC) reduced the implantation of H. contortus larvae in lambs.•ThLVC-induced protection is associated to the expression of certain types of cytokines.•The ThLVC is a non-specific immune stimulator for the abomasal immune response.
The abomasal expression of IL-2, IL-4, IL-6, IL-10 and IFNγ in lambs experimentally infected with Haemonchus contortus and its relationship to protection induced by a Taenia hydatigena larvae vesicular concentrate (ThLVC) were evaluated. The lambs that were only infected with H. contortus larvae showed a worm burden greater (p |
| doi_str_mv | 10.1016/j.vetpar.2015.04.019 |
| format | Article |
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The abomasal expression of IL-2, IL-4, IL-6, IL-10 and IFNγ in lambs experimentally infected with Haemonchus contortus and its relationship to protection induced by a Taenia hydatigena larvae vesicular concentrate (ThLVC) were evaluated. The lambs that were only infected with H. contortus larvae showed a worm burden greater (p<0.05) than the lambs that received ThLVC prior to infection. Moreover, the lambs that received ThLVC showed a greater (p<0.05) number of blood eosinophils than the lambs that did not receive the ThLVC. In general, the lambs that received ThLVC prior to infection had a greater amount of eosinophils and mast cells and higher in situ expression of IFNγ, IL-2, IL-4, IL-6 and IL-10 in the abomasal wall than the lambs that were infected with H. contortus only or that received ThLVC (p<0.05) only. A higher expression of IL-2 and IFNγ in the submucosa compared to the abomasal mucosa and a higher expression of IL-4 in the abomasal mucosa compared to the submucosa was observed (p<0.05). These results suggest that there is a Th1 type response in the abomasal submucosa and a Th2 type response in in the abomasal mucosa. The amount of eosinophils and mast cells and the in situ expression of IFNγ, IL-2, IL-4 and IL-6 in the abomasal walls were negatively correlated with the worm burden (p<0.05). These results suggest that ThLVC is a non-specific immune stimulator for the abomasal immune response, and it is likely that the protection observed is the result of this effect.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2015.04.019</identifier><identifier>PMID: 25959643</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abomasal wall ; Abomasum - immunology ; Animals ; Cytokines ; Cytokines - immunology ; Eosinophils - immunology ; Female ; Haemonchiasis - immunology ; Haemonchiasis - veterinary ; Haemonchus - immunology ; Immune protection ; Immunohistochemistry ; Leukocyte Count - veterinary ; Male ; Mast Cells - immunology ; Ovine haemonchosis ; Parasite Egg Count - veterinary ; Sheep ; Sheep Diseases - immunology ; Taenia - immunology</subject><ispartof>Veterinary parasitology, 2015-06, Vol.211 (1-2), p.60-66</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-4acad3a2d1d03f111a4d158d05d3e1f033e0dc2a538a43c29e8d69a3f1766e2b3</citedby><cites>FETCH-LOGICAL-c432t-4acad3a2d1d03f111a4d158d05d3e1f033e0dc2a538a43c29e8d69a3f1766e2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetpar.2015.04.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25959643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buendía-Jiménez, J.A.</creatorcontrib><creatorcontrib>Muñoz-Guzmán, M.A.</creatorcontrib><creatorcontrib>Vega-López, M.A.</creatorcontrib><creatorcontrib>Cuenca-Verde, C.</creatorcontrib><creatorcontrib>Martínez-Labat, J.P.</creatorcontrib><creatorcontrib>Cuéllar-Ordaz, J.A.</creatorcontrib><creatorcontrib>Alba-Hurtado, F.</creatorcontrib><title>Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>•The administration of a Taenia hydatigena larvae vesicular concentrate (ThLVC) reduced the implantation of H. contortus larvae in lambs.•ThLVC-induced protection is associated to the expression of certain types of cytokines.•The ThLVC is a non-specific immune stimulator for the abomasal immune response.
The abomasal expression of IL-2, IL-4, IL-6, IL-10 and IFNγ in lambs experimentally infected with Haemonchus contortus and its relationship to protection induced by a Taenia hydatigena larvae vesicular concentrate (ThLVC) were evaluated. The lambs that were only infected with H. contortus larvae showed a worm burden greater (p<0.05) than the lambs that received ThLVC prior to infection. Moreover, the lambs that received ThLVC showed a greater (p<0.05) number of blood eosinophils than the lambs that did not receive the ThLVC. In general, the lambs that received ThLVC prior to infection had a greater amount of eosinophils and mast cells and higher in situ expression of IFNγ, IL-2, IL-4, IL-6 and IL-10 in the abomasal wall than the lambs that were infected with H. contortus only or that received ThLVC (p<0.05) only. A higher expression of IL-2 and IFNγ in the submucosa compared to the abomasal mucosa and a higher expression of IL-4 in the abomasal mucosa compared to the submucosa was observed (p<0.05). These results suggest that there is a Th1 type response in the abomasal submucosa and a Th2 type response in in the abomasal mucosa. The amount of eosinophils and mast cells and the in situ expression of IFNγ, IL-2, IL-4 and IL-6 in the abomasal walls were negatively correlated with the worm burden (p<0.05). These results suggest that ThLVC is a non-specific immune stimulator for the abomasal immune response, and it is likely that the protection observed is the result of this effect.</description><subject>Abomasal wall</subject><subject>Abomasum - immunology</subject><subject>Animals</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Haemonchiasis - immunology</subject><subject>Haemonchiasis - veterinary</subject><subject>Haemonchus - immunology</subject><subject>Immune protection</subject><subject>Immunohistochemistry</subject><subject>Leukocyte Count - veterinary</subject><subject>Male</subject><subject>Mast Cells - immunology</subject><subject>Ovine haemonchosis</subject><subject>Parasite Egg Count - veterinary</subject><subject>Sheep</subject><subject>Sheep Diseases - immunology</subject><subject>Taenia - immunology</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotOWN0DISzYJduz8bZBQVShSpbJo19Yd-4bxkNjBdqbMM_UlcTSlS1a2rr5zru45hLznrOSMN5_25QHTDKGsGK9LJkvG-1dkw7tWFFVds9dkwwSThWS8PSPnMe4ZY5I17VtyVtV93TdSbMjTDwjJwkjn4BPqZL2j4AyFrZ8g5rk-Jv_LOqT4Zw4Y4wpYR-MOcV5nGOyELsE4HvN8yBZo6KNNO3oDOHmnd0uk2rvkQ8q_1Tv7FCkgvJD3gM4C3R0NJPsTHdADRquXEcIq1dk_ZPqSvBlgjPju-b0gD1-v769uitu7b9-vvtwWWooqFRI0GAGV4YaJgXMO0vC6M6w2AvnAhEBmdAW16EAKXfXYmaaHjLZNg9VWXJCPJ9-cye8FY1KTjRrHERz6JSredG3f910tMipPqA4-xoCDmnMeEI6KM7XWpPbqVJNaa1JMqlxTln143rBsJzQvon-9ZODzCcB858FiUFFbzEkYG3LEynj7_w1_Ad5Rq7k</recordid><startdate>20150630</startdate><enddate>20150630</enddate><creator>Buendía-Jiménez, J.A.</creator><creator>Muñoz-Guzmán, M.A.</creator><creator>Vega-López, M.A.</creator><creator>Cuenca-Verde, C.</creator><creator>Martínez-Labat, J.P.</creator><creator>Cuéllar-Ordaz, J.A.</creator><creator>Alba-Hurtado, F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150630</creationdate><title>Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate</title><author>Buendía-Jiménez, J.A. ; Muñoz-Guzmán, M.A. ; Vega-López, M.A. ; Cuenca-Verde, C. ; Martínez-Labat, J.P. ; Cuéllar-Ordaz, J.A. ; Alba-Hurtado, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-4acad3a2d1d03f111a4d158d05d3e1f033e0dc2a538a43c29e8d69a3f1766e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abomasal wall</topic><topic>Abomasum - immunology</topic><topic>Animals</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Haemonchiasis - immunology</topic><topic>Haemonchiasis - veterinary</topic><topic>Haemonchus - immunology</topic><topic>Immune protection</topic><topic>Immunohistochemistry</topic><topic>Leukocyte Count - veterinary</topic><topic>Male</topic><topic>Mast Cells - immunology</topic><topic>Ovine haemonchosis</topic><topic>Parasite Egg Count - veterinary</topic><topic>Sheep</topic><topic>Sheep Diseases - immunology</topic><topic>Taenia - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buendía-Jiménez, J.A.</creatorcontrib><creatorcontrib>Muñoz-Guzmán, M.A.</creatorcontrib><creatorcontrib>Vega-López, M.A.</creatorcontrib><creatorcontrib>Cuenca-Verde, C.</creatorcontrib><creatorcontrib>Martínez-Labat, J.P.</creatorcontrib><creatorcontrib>Cuéllar-Ordaz, J.A.</creatorcontrib><creatorcontrib>Alba-Hurtado, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buendía-Jiménez, J.A.</au><au>Muñoz-Guzmán, M.A.</au><au>Vega-López, M.A.</au><au>Cuenca-Verde, C.</au><au>Martínez-Labat, J.P.</au><au>Cuéllar-Ordaz, J.A.</au><au>Alba-Hurtado, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2015-06-30</date><risdate>2015</risdate><volume>211</volume><issue>1-2</issue><spage>60</spage><epage>66</epage><pages>60-66</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>•The administration of a Taenia hydatigena larvae vesicular concentrate (ThLVC) reduced the implantation of H. contortus larvae in lambs.•ThLVC-induced protection is associated to the expression of certain types of cytokines.•The ThLVC is a non-specific immune stimulator for the abomasal immune response.
The abomasal expression of IL-2, IL-4, IL-6, IL-10 and IFNγ in lambs experimentally infected with Haemonchus contortus and its relationship to protection induced by a Taenia hydatigena larvae vesicular concentrate (ThLVC) were evaluated. The lambs that were only infected with H. contortus larvae showed a worm burden greater (p<0.05) than the lambs that received ThLVC prior to infection. Moreover, the lambs that received ThLVC showed a greater (p<0.05) number of blood eosinophils than the lambs that did not receive the ThLVC. In general, the lambs that received ThLVC prior to infection had a greater amount of eosinophils and mast cells and higher in situ expression of IFNγ, IL-2, IL-4, IL-6 and IL-10 in the abomasal wall than the lambs that were infected with H. contortus only or that received ThLVC (p<0.05) only. A higher expression of IL-2 and IFNγ in the submucosa compared to the abomasal mucosa and a higher expression of IL-4 in the abomasal mucosa compared to the submucosa was observed (p<0.05). These results suggest that there is a Th1 type response in the abomasal submucosa and a Th2 type response in in the abomasal mucosa. The amount of eosinophils and mast cells and the in situ expression of IFNγ, IL-2, IL-4 and IL-6 in the abomasal walls were negatively correlated with the worm burden (p<0.05). These results suggest that ThLVC is a non-specific immune stimulator for the abomasal immune response, and it is likely that the protection observed is the result of this effect.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25959643</pmid><doi>10.1016/j.vetpar.2015.04.019</doi><tpages>7</tpages></addata></record> |
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| subjects | Abomasal wall Abomasum - immunology Animals Cytokines Cytokines - immunology Eosinophils - immunology Female Haemonchiasis - immunology Haemonchiasis - veterinary Haemonchus - immunology Immune protection Immunohistochemistry Leukocyte Count - veterinary Male Mast Cells - immunology Ovine haemonchosis Parasite Egg Count - veterinary Sheep Sheep Diseases - immunology Taenia - immunology |
| title | Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate |
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