Experimental Substantiation for the Use of Mexidol and 3-Hydroxypyridine Fumarate in Chronic Myocardial Injury
We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2013-06, Vol.155 (2), p.212-213 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 155 |
| creator | Zamotaeva, M. N. Chairkin, I. N. Inchina, V. I. Drozdov, I. A. |
| description | We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg). |
| doi_str_mv | 10.1007/s10517-013-2115-3 |
| format | Article |
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| subjects | Animals Antioxidants - therapeutic use Aspartate Aminotransferases - blood Biomedical and Life Sciences Biomedicine Cell Biology Energy Metabolism - drug effects Heart Failure - drug therapy Internal Medicine Laboratory Medicine Malondialdehyde - blood Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Pathology Picolines - therapeutic use Platelet Aggregation Inhibitors - therapeutic use Potassium - blood Pyridines - therapeutic use Rats |
| title | Experimental Substantiation for the Use of Mexidol and 3-Hydroxypyridine Fumarate in Chronic Myocardial Injury |
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