Experimental Substantiation for the Use of Mexidol and 3-Hydroxypyridine Fumarate in Chronic Myocardial Injury

We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-06, Vol.155 (2), p.212-213
Hauptverfasser:	Zamotaeva, M. N., Chairkin, I. N., Inchina, V. I., Drozdov, I. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - therapeutic use Aspartate Aminotransferases - blood Biomedical and Life Sciences Biomedicine Cell Biology Energy Metabolism - drug effects Heart Failure - drug therapy Internal Medicine Laboratory Medicine Malondialdehyde - blood Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Pathology Picolines - therapeutic use Platelet Aggregation Inhibitors - therapeutic use Potassium - blood Pyridines - therapeutic use Rats
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Beschreibung
Zusammenfassung:	We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2115-3