The role of nitric oxide in the PKA inhibitor induced spatial memory deficits in rat: Involvement of choline acetyltransferase

Several lines of evidence show that cAMP-PKA signaling pathway plays critical role in memory functions and suggest nitric oxide as an important modulator in learning and memory. In this study, we assessed the effects of intra-hippocampal infusion of H-89, a selective PKAII inhibitor, and 1400W, a se...

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Veröffentlicht in:	European journal of pharmacology 2013-08, Vol.714 (1-3), p.478-485
Hauptverfasser:	Najafi, Sheyda, Payandemehr, Borna, Tabrizian, Kaveh, Shariatpanahi, Marjan, Nassireslami, Ehsan, Azami, Kian, Mohammadi, Mojdeh, Asadi, Farideh, Roghani, Ali, Sharifzadeh, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cAMP-dependent protein kinase choline acetyltransferase Choline O-Acetyltransferase - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Drug Interactions Escape Reaction - drug effects Escape Reaction - physiology Gene Expression Regulation, Enzymologic - drug effects hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Imines - pharmacology immunohistochemistry Inducible nitric oxide synthase Isoquinolines - pharmacology Male Maze Learning - drug effects Maze Learning - physiology memory Memory - drug effects Morris water maze nitric oxide Nitric Oxide - metabolism pharmacology Phosphorylation - drug effects protective effect Protein kinase A Protein Kinase Inhibitors - pharmacology Rats Rats, Wistar Septal Nuclei - drug effects Septal Nuclei - metabolism Septal Nuclei - physiology signal transduction Spatial Behavior - drug effects Spatial Behavior - physiology Spatial memory Sulfonamides - pharmacology Swimming
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Zusammenfassung:	Several lines of evidence show that cAMP-PKA signaling pathway plays critical role in memory functions and suggest nitric oxide as an important modulator in learning and memory. In this study, we assessed the effects of intra-hippocampal infusion of H-89, a selective PKAII inhibitor, and 1400W, a selective inducible nitric oxide synthase (iNOS) inhibitor, on spatial memory in rats. By using the Morris water maze, spatial memory retention parameters were examined 48h after the infusions through measuring escape latency, traveled distance, and swimming speed. The rats receiving intra-hippocampal infusions of 1400W (100µM/side) showed a significant reduction (⁎P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/j.ejphar.2013.06.039