Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp

Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp

Three new polyketide compounds (1–3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were el...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2013-09, Vol.76 (9), p.1535-1540
Hauptverfasser: Gan, Maoluo, Liu, Yufeng, Bai, Yinlei, Guan, Yan, Li, Li, Gao, Rongmei, He, Weiying, You, Xuefu, Li, Yuhuan, Yu, Liyan, Xiao, Chunling
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
beta-Lactamase Inhibitors
beta-Lactamases
China
Circular Dichroism
Crystallography, X-Ray
Inhibitory Concentration 50
Molecular Structure
Penicillium
Penicillium - chemistry
Picea
Polyketides - chemistry
Polyketides - isolation & purification
Polyketides - pharmacology
Quinolones - chemistry
Quinolones - isolation & purification
Quinolones - pharmacology
Rhizosphere
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Zusammenfassung:Three new polyketide compounds (1–3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey’s method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-β-lactamase 1 with IC50 values of 94.9 and 87.9 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np4000944