Vasomotor Activity of the Aorta during Chronic Smoking Modeling

We studied vasomotor responses of aortic endothelium in a rat model of chronic smoking. It was found that long-term exposure to tobacco smoke (inhalation) impaired vasomotor function of the aortic endothelium leading to insufficient vasodilator activity and enhanced vasoconstriction. After the cessa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-07, Vol.155 (3), p.302-305
Hauptverfasser:	Zakharchuk, N. V., Nevzorova, V. A., Gonchar, E. Y., Agafonova, I. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - physiopathology Biomedical and Life Sciences Biomedicine Blood vessels Cardiovascular diseases Cell Biology Dilatation Disease Models, Animal Endothelial Cells - physiology General Pathology and Pathophysiology Internal Medicine Laboratory Medicine Lung diseases, Obstructive Magnetic Resonance Imaging Pathology Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Rats Smoking Smoking - adverse effects Smoking - physiopathology Statistics, Nonparametric Vasoconstriction - physiology Vasodilators Vasomotor System - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We studied vasomotor responses of aortic endothelium in a rat model of chronic smoking. It was found that long-term exposure to tobacco smoke (inhalation) impaired vasomotor function of the aortic endothelium leading to insufficient vasodilator activity and enhanced vasoconstriction. After the cessation of inhalations, vasomotor disturbances were not only preserved, but also exacerbated because of increased pathological endothelium-independent vasoconstriction.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2138-9