Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation

Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation

We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the delayed period after combined exposure to a sublethal dose of γ-radiation (6 Gy) and asbestos dust particles. Combined exposure...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2013-04, Vol.154 (6), p.747-749
Hauptverfasser: Tapbergenov, S. O., Zhetpisbaev, B. A., Ilderbayev, O. Z., Zhetpisbaeva, H. S., Olzhayeva, R. R., Prozor, I. I., Usenova, O. A., Ilderbayeva, G. O.
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological
Adrenal Glands - metabolism
Adrenal Glands - radiation effects
Animals
Animals, Outbred Strains
Antioxidants
Asbestos - toxicity
Biomedical and Life Sciences
Biomedicine
Carcinogens - toxicity
Cell Biology
Disease Models, Animal
Dust
Free Radicals - metabolism
Humans
Internal Medicine
Laboratory Medicine
Lipid Peroxidation
Liver - metabolism
Liver - radiation effects
Lymph Nodes - metabolism
Lymph Nodes - radiation effects
Male
Malondialdehyde - metabolism
Nuclear radiation
Occupational Exposure
Organ Specificity
Oxidation-Reduction
Oxidative Stress
Pathology
Radioactive Pollutants - toxicity
Rats
Spleen - metabolism
Spleen - radiation effects
Thymus Gland - metabolism
Thymus Gland - radiation effects
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Zusammenfassung:We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the delayed period after combined exposure to a sublethal dose of γ-radiation (6 Gy) and asbestos dust particles. Combined exposure was followed by accumulation of LPO metabolites (diene conjugates and malonic dialdehyde) in homogenates of the studied organs and resulted in antioxidant defense failure in experimental animals. Ionizing radiation have a pivotal role in these processes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2046-z