Effect of Supernatant from Fibroblasts from the Progeny of Female Rats with Chronic Liver Disease of Different Origin on the Morphology and Function of Cultured Peritoneal Macrophages

We studied the effects of supernatant from ovarian fibroblasts derived from the progeny of female rats with experimental chronic liver disease of different genesis on the function of cultured allogenic peritoneal macrophages. Addition of fibroblast supernatant derived from animals with liver disease to the culture medium suppressed the function of peritoneal macrophages from intact newborn rats, which manifested in reduction of the adhesion characteristics and decrease of their phagocytic parameter and phagocytic index.