Effects of lead nitrate and sodium selenite on DNA damage and oxidative stress in diabetic and non-diabetic rat erythrocytes and leucocytes

Highlights • Lead nitrate and diabetes mellitus caused toxicity in rat blood. • Lead nitrate caused more harmful effects in diabetic groups compared with non-diabetic groups. • Sodium selenite protected against the toxicity induced by lead nitrate. • Protective effect of sodium selenite was not seen...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-05, Vol.39 (3), p.1019-1026
Hauptverfasser:	Baş, Hatice, Kalender, Yusuf, Pandir, Dilek, Kalender, Suna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant enzyme Catalase - blood Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - enzymology DNA damage DNA Damage - drug effects Emergency Erythrocytes - drug effects Gene Expression Regulation, Enzymologic - drug effects Glutathione Peroxidase - blood Glutathione Transferase - blood Lead Lead - adverse effects Leukocytes - drug effects Malondialdehyde - blood Nitrates - adverse effects Oxidative stress Oxidative Stress - drug effects Rats Selenium Sodium Selenite - administration & dosage Sodium Selenite - pharmacology Superoxide Dismutase - blood
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Beschreibung
Zusammenfassung:	Highlights • Lead nitrate and diabetes mellitus caused toxicity in rat blood. • Lead nitrate caused more harmful effects in diabetic groups compared with non-diabetic groups. • Sodium selenite protected against the toxicity induced by lead nitrate. • Protective effect of sodium selenite was not seen against diabetes mellitus induced toxicity.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.03.012