Thrombopoietin Induces Megakaryocyte Differentiation in Hematopoietic Progenitor FDC-P2 Cells (∗)

Thrombopoietin (Tpo) is a cytokine that specifically regulates megakaryocyte maturation and platelet production. Little is known about the molecular and cellular mechanism of the Tpo-induced megakaryocyte maturation process including polyploidization and platelet release. To study Tpo-induced megaka...

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Veröffentlicht in:	The Journal of biological chemistry 1995-08, Vol.270 (34), p.19673-19675
Hauptverfasser:	Nagata, Yuka, Nagahisa, Hiroshi, Aida, Yoko, Okutomi, Keiichi, Nagasawa, Toshiro, Todokoro, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - biosynthesis Cell Differentiation - drug effects Cell Division - drug effects Cell Line DNA-Binding Proteins - biosynthesis Erythroid-Specific DNA-Binding Factors GATA1 Transcription Factor Hematopoiesis - drug effects Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - metabolism Mice Neoplasm Proteins NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit Platelet Membrane Glycoproteins - biosynthesis Proto-Oncogene Proteins - drug effects Receptors, Cytokine Receptors, Immunologic - drug effects Receptors, Thrombopoietin Thrombopoietin - pharmacology Transcription Factors - biosynthesis
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