Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl- 1H-benzimidazole derivatives

Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl- 1H-benzimidazole derivatives

A series of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1 -benzimidazoles ( ) were synthesized and evaluated for their in vitro antiproliferative activities against the human leukemia cell line HL-60. Compounds and exhibited potent antiproliferative activities against this cell line. The quantitative...

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Veröffentlicht in:Zeitschrift für Naturforschung C. A journal of biosciences 2015-03, Vol.70 (3), p.79-85
Hauptverfasser: Alp, Mehmet, Gurkan-Alp, A. Selen, Ozkan, Tulin, Sunguroglu, Asuman
Format: Artikel
Sprache:eng
Schlagworte:
AML
antiproliferative activity
apoptosis
Apoptosis - drug effects
benzimidazole
Benzimidazoles - chemical synthesis
Benzimidazoles - chemistry
Benzimidazoles - pharmacology
Cell Proliferation - drug effects
Flow Cytometry
HL-60
HL-60 Cells
Humans
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Zusammenfassung:A series of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1 -benzimidazoles ( ) were synthesized and evaluated for their in vitro antiproliferative activities against the human leukemia cell line HL-60. Compounds and exhibited potent antiproliferative activities against this cell line. The quantitative analysis of apoptosis by flow cytometry demonstrated that the percentages of apoptotic HL-60 cells treated with compounds and were significantly higher than in the control.
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-2014-4189