Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gen...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-05, Vol.51 (40), p.8473-8476
Hauptverfasser: Huang, Jian-Yuan, Gao, Yongsheng, Cutlar, Lara, O'Keeffe-Ahern, Jonathan, Zhao, Tianyu, Lin, Feng-Huei, Zhou, Dezhong, McMahon, Sean, Greiser, Udo, Wang, Wei, Wang, Wenxin
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Branched
Cell Survival
Esters
Gene therapy
Gene Transfer Techniques
Genes
Genetic Therapy
Human
Humans
Joining
Keratinocytes - metabolism
Luciferases - genetics
Platforms
Polyetherimides
Polymers - chemistry
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Zusammenfassung:Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc02193f