MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes

Highlights • MicroRNA (miRNA) deregulation is involved in the development of myelodysplastic syndrome (MDS). • The expression of nine miRNAs encoded by chromosome 8 and three miRNAs encoded by chromosome 1q was assessed. • miR-194-5p is a candidate diagnostic biomarker for MDS. • Low miR-194-5p expr...

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Veröffentlicht in:	Leukemia research 2015-07, Vol.39 (7), p.763-768
Hauptverfasser:	Choi, Ji-Seon, Nam, Myung-Hyun, Yoon, Soo-Young, Kang, Seong-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Deregulation Diagnosis Female Hematology, Oncology and Palliative Medicine Humans Male MDS microRNA MicroRNAs - genetics Middle Aged Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - physiopathology Prognosis
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Beschreibung
Zusammenfassung:	Highlights • MicroRNA (miRNA) deregulation is involved in the development of myelodysplastic syndrome (MDS). • The expression of nine miRNAs encoded by chromosome 8 and three miRNAs encoded by chromosome 1q was assessed. • miR-194-5p is a candidate diagnostic biomarker for MDS. • Low miR-194-5p expression could be associated with poor overall survival for MDS.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.04.013