Prospects for a nicotine-reduction strategy in the cigarette endgame: Alternative tobacco harm reduction scenarios

Highlights • A mandatory nicotine-reduction strategy has been favoured in the cigarette endgame. • Prospects for U.S. FDA law to succeed in doing this are argued to be not good. • And, if the strategy is practicable, it will take several years to implement. • Waiting for a nicotine-reduction strategy creates significant opportunity costs. • Nicotine-maintaining harm-reduction strategies should not be delayed.