Bactibilia and Antibiotic Resistance in Elective Cholecysctectomy: An Updated Ecologic Survey
Background: The role of bactibilia as a risk factor for an unfavorable outcome during biliary disease or surgical procedures remains obscure. Our aim was to identify possible risk factors for bactibilia and their possible relations to complications after elective cholecystectomy. As secondary aims,...
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Veröffentlicht in: | Surgical infections 2015-06, Vol.16 (3), p.287-292 |
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creator | Troyano Escribano, Daniel Balibrea Del Castillo, José M. Molinos Abós, Sònia Vicente, Ausina Ruiz Fernandez-Llamazares Rodriguez, Jaime Oller Sales, Benjamin |
description | Background:
The role of bactibilia as a risk factor for an unfavorable outcome during biliary disease or surgical procedures remains obscure. Our aim was to identify possible risk factors for bactibilia and their possible relations to complications after elective cholecystectomy. As secondary aims, composition and antibiotic resistance patterns were studied.
Methods:
Bile and gallbladder mucosa samples from 358 elective cholecystectomies were collected prospectively between June 2009 and June 2012. Ordinary microbiologic cultures and antibiograms were performed. All pre-operative factors associated with bactibilia were studied by stepwise logistic regression multivariable analysis.
Results:
The bacteria isolated most frequently from 103 positive cultures were
Escherichia coli
(21.3%),
Enterococcus
spp. (14.7%), and
Enterobacter
spp. (14.7%) with a global amoxicillin-clavulanic acid resistance rate of 53.7%. Age >65 y, male gender, previous instrumentation or disease of the biliary tract, and high American Society of Anesthesiologists score were independent risk factors. No correlation was found between bactibilia and surgical complications.
Conclusions:
Although the influence of bactibilia in developing surgical complications is limited, its composition and the high rate of resistance can be influential enough to modify antibiotic treatment in biliary tract infections, especially in high-risk patients. |
doi_str_mv | 10.1089/sur.2014.023 |
format | Article |
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The role of bactibilia as a risk factor for an unfavorable outcome during biliary disease or surgical procedures remains obscure. Our aim was to identify possible risk factors for bactibilia and their possible relations to complications after elective cholecystectomy. As secondary aims, composition and antibiotic resistance patterns were studied.
Methods:
Bile and gallbladder mucosa samples from 358 elective cholecystectomies were collected prospectively between June 2009 and June 2012. Ordinary microbiologic cultures and antibiograms were performed. All pre-operative factors associated with bactibilia were studied by stepwise logistic regression multivariable analysis.
Results:
The bacteria isolated most frequently from 103 positive cultures were
Escherichia coli
(21.3%),
Enterococcus
spp. (14.7%), and
Enterobacter
spp. (14.7%) with a global amoxicillin-clavulanic acid resistance rate of 53.7%. Age >65 y, male gender, previous instrumentation or disease of the biliary tract, and high American Society of Anesthesiologists score were independent risk factors. No correlation was found between bactibilia and surgical complications.
Conclusions:
Although the influence of bactibilia in developing surgical complications is limited, its composition and the high rate of resistance can be influential enough to modify antibiotic treatment in biliary tract infections, especially in high-risk patients.</description><identifier>ISSN: 1096-2964</identifier><identifier>EISSN: 1557-8674</identifier><identifier>DOI: 10.1089/sur.2014.023</identifier><identifier>PMID: 25897984</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteria - classification ; Bacteria - drug effects ; Bacteria - isolation & purification ; Bacteriological Techniques ; Bile - microbiology ; Cholecystectomy ; Drug Resistance, Bacterial ; Female ; Gallbladder - microbiology ; Humans ; Male ; Middle Aged ; Original Articles ; Prospective Studies ; Young Adult</subject><ispartof>Surgical infections, 2015-06, Vol.16 (3), p.287-292</ispartof><rights>2015, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-3a7ae9af77a85cbfa36c44aa1be1063d18e257824228bdf6e2f7c638fd4d3d8d3</citedby><cites>FETCH-LOGICAL-c334t-3a7ae9af77a85cbfa36c44aa1be1063d18e257824228bdf6e2f7c638fd4d3d8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25897984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Troyano Escribano, Daniel</creatorcontrib><creatorcontrib>Balibrea Del Castillo, José M.</creatorcontrib><creatorcontrib>Molinos Abós, Sònia</creatorcontrib><creatorcontrib>Vicente, Ausina Ruiz</creatorcontrib><creatorcontrib>Fernandez-Llamazares Rodriguez, Jaime</creatorcontrib><creatorcontrib>Oller Sales, Benjamin</creatorcontrib><title>Bactibilia and Antibiotic Resistance in Elective Cholecysctectomy: An Updated Ecologic Survey</title><title>Surgical infections</title><addtitle>Surg Infect (Larchmt)</addtitle><description>Background:
The role of bactibilia as a risk factor for an unfavorable outcome during biliary disease or surgical procedures remains obscure. Our aim was to identify possible risk factors for bactibilia and their possible relations to complications after elective cholecystectomy. As secondary aims, composition and antibiotic resistance patterns were studied.
Methods:
Bile and gallbladder mucosa samples from 358 elective cholecystectomies were collected prospectively between June 2009 and June 2012. Ordinary microbiologic cultures and antibiograms were performed. All pre-operative factors associated with bactibilia were studied by stepwise logistic regression multivariable analysis.
Results:
The bacteria isolated most frequently from 103 positive cultures were
Escherichia coli
(21.3%),
Enterococcus
spp. (14.7%), and
Enterobacter
spp. (14.7%) with a global amoxicillin-clavulanic acid resistance rate of 53.7%. Age >65 y, male gender, previous instrumentation or disease of the biliary tract, and high American Society of Anesthesiologists score were independent risk factors. No correlation was found between bactibilia and surgical complications.
Conclusions:
Although the influence of bactibilia in developing surgical complications is limited, its composition and the high rate of resistance can be influential enough to modify antibiotic treatment in biliary tract infections, especially in high-risk patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bacteriological Techniques</subject><subject>Bile - microbiology</subject><subject>Cholecystectomy</subject><subject>Drug Resistance, Bacterial</subject><subject>Female</subject><subject>Gallbladder - microbiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Articles</subject><subject>Prospective Studies</subject><subject>Young Adult</subject><issn>1096-2964</issn><issn>1557-8674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAQRi0EomW5cUY5ciDFW2yHW6nKIlVCAnpEkWNPwChLiZNK-fc4auHIaWY-vfkOD6ELgmcEq_TG9-2MYsJnmLIDNCVJImMlJD8MO05FTFPBJ-jE-y-MiaRCHKMJTVQqU8Wn6P1Om87lrnQ60rWN5vV4NZ0z0Qt45ztdG4hcHS1LCOAWosVnE9bBmy4ETTXchp9ovbG6AxstTVM2H-H5tW-3MJyho0KXHs738xSt75dvi8d49fzwtJivYsMY72KmpYZUF1JqlZi80EwYzrUmORAsmCUKaCIV5ZSq3BYCaCGNYKqw3DKrLDtFV7veTdt89-C7rHLeQFnqGpreZ0QowQmRJAno9Q41beN9C0W2aV2l2yEjOBuFZkFoNgrNgtCAX-6b-7wC-wf_GgwA3QFjrOu6dJBD2_3f-gPwy4OS</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Troyano Escribano, Daniel</creator><creator>Balibrea Del Castillo, José M.</creator><creator>Molinos Abós, Sònia</creator><creator>Vicente, Ausina Ruiz</creator><creator>Fernandez-Llamazares Rodriguez, Jaime</creator><creator>Oller Sales, Benjamin</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Bactibilia and Antibiotic Resistance in Elective Cholecysctectomy: An Updated Ecologic Survey</title><author>Troyano Escribano, Daniel ; Balibrea Del Castillo, José M. ; Molinos Abós, Sònia ; Vicente, Ausina Ruiz ; Fernandez-Llamazares Rodriguez, Jaime ; Oller Sales, Benjamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-3a7ae9af77a85cbfa36c44aa1be1063d18e257824228bdf6e2f7c638fd4d3d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacteria - classification</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bacteriological Techniques</topic><topic>Bile - microbiology</topic><topic>Cholecystectomy</topic><topic>Drug Resistance, Bacterial</topic><topic>Female</topic><topic>Gallbladder - microbiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Articles</topic><topic>Prospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Troyano Escribano, Daniel</creatorcontrib><creatorcontrib>Balibrea Del Castillo, José M.</creatorcontrib><creatorcontrib>Molinos Abós, Sònia</creatorcontrib><creatorcontrib>Vicente, Ausina Ruiz</creatorcontrib><creatorcontrib>Fernandez-Llamazares Rodriguez, Jaime</creatorcontrib><creatorcontrib>Oller Sales, Benjamin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Troyano Escribano, Daniel</au><au>Balibrea Del Castillo, José M.</au><au>Molinos Abós, Sònia</au><au>Vicente, Ausina Ruiz</au><au>Fernandez-Llamazares Rodriguez, Jaime</au><au>Oller Sales, Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bactibilia and Antibiotic Resistance in Elective Cholecysctectomy: An Updated Ecologic Survey</atitle><jtitle>Surgical infections</jtitle><addtitle>Surg Infect (Larchmt)</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>16</volume><issue>3</issue><spage>287</spage><epage>292</epage><pages>287-292</pages><issn>1096-2964</issn><eissn>1557-8674</eissn><abstract>Background:
The role of bactibilia as a risk factor for an unfavorable outcome during biliary disease or surgical procedures remains obscure. Our aim was to identify possible risk factors for bactibilia and their possible relations to complications after elective cholecystectomy. As secondary aims, composition and antibiotic resistance patterns were studied.
Methods:
Bile and gallbladder mucosa samples from 358 elective cholecystectomies were collected prospectively between June 2009 and June 2012. Ordinary microbiologic cultures and antibiograms were performed. All pre-operative factors associated with bactibilia were studied by stepwise logistic regression multivariable analysis.
Results:
The bacteria isolated most frequently from 103 positive cultures were
Escherichia coli
(21.3%),
Enterococcus
spp. (14.7%), and
Enterobacter
spp. (14.7%) with a global amoxicillin-clavulanic acid resistance rate of 53.7%. Age >65 y, male gender, previous instrumentation or disease of the biliary tract, and high American Society of Anesthesiologists score were independent risk factors. No correlation was found between bactibilia and surgical complications.
Conclusions:
Although the influence of bactibilia in developing surgical complications is limited, its composition and the high rate of resistance can be influential enough to modify antibiotic treatment in biliary tract infections, especially in high-risk patients.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>25897984</pmid><doi>10.1089/sur.2014.023</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Bacteria - classification Bacteria - drug effects Bacteria - isolation & purification Bacteriological Techniques Bile - microbiology Cholecystectomy Drug Resistance, Bacterial Female Gallbladder - microbiology Humans Male Middle Aged Original Articles Prospective Studies Young Adult |
title | Bactibilia and Antibiotic Resistance in Elective Cholecysctectomy: An Updated Ecologic Survey |
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