Oral 5-aminolevulinic acid mediated photodynamic diagnosis using fluorescence cystoscopy for non-muscle-invasive bladder cancer: A randomized, double-blind, multicentre phase II/III study

Oral 5-aminolevulinic acid mediated photodynamic diagnosis using fluorescence cystoscopy for non-muscle-invasive bladder cancer: A randomized, double-blind, multicentre phase II/III study

Highlights • The investigator-initiated clinical trial confirmed the efficacy and safety of PDD. • The clinical trial confirmed the utility of oral 5-ALA-mediated PDD for NMIBC. • The efficacy and safety of oral 5-ALA-mediated PDD for blader cancer were confirmed.

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Veröffentlicht in:Photodiagnosis and photodynamic therapy 2015-06, Vol.12 (2), p.193-200
Hauptverfasser: Inoue, Keiji, Anai, Satoshi, Fujimoto, Kiyohide, Hirao, Yoshihiko, Furuse, Hiroshi, Kai, Fumitake, Ozono, Seiichiro, Hara, Takahiko, Matsuyama, Hideyasu, Oyama, Masafumi, Ueno, Munehisa, Fukuhara, Hideo, Narukawa, Mamoru, Shuin, Taro
Format: Artikel
Sprache:eng
Schlagworte:
5-Aminolevulinic acid
Adult
Aged
Aged, 80 and over
Aminolevulinic Acid - administration & dosage
Aminolevulinic Acid - adverse effects
Aminolevulinic Acid - analogs & derivatives
Aminolevulinic Acid - therapeutic use
Cystoscopy - methods
Dose-Response Relationship, Drug
Double-Blind Method
Female
Fluorescence
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Male
Middle Aged
Non-muscle-invasive bladder cancer
Oral administration
Photochemotherapy - methods
Photodynamic diagnosis
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - adverse effects
Photosensitizing Agents - therapeutic use
Randomized clinical trial
Sensitivity and Specificity
Urinary Bladder Neoplasms - diagnosis
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Zusammenfassung:Highlights • The investigator-initiated clinical trial confirmed the efficacy and safety of PDD. • The clinical trial confirmed the utility of oral 5-ALA-mediated PDD for NMIBC. • The efficacy and safety of oral 5-ALA-mediated PDD for blader cancer were confirmed.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2015.03.008