Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen

Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of po...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-06, Vol.13 (23), p.6468-6473
Hauptverfasser:	Barbera, Lucia, Gattuso, Giuseppe, Kohnke, Franz H, Notti, Anna, Pappalardo, Sebastiano, Parisi, Melchiorre F, Pisagatti, Ilenia, Patanè, Salvatore, Micali, Norberto, Villari, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions - chemistry Calixarenes - chemistry Dynamic Light Scattering Flurbiprofen - chemistry Magnetic Resonance Spectroscopy Micelles Microscopy, Atomic Force Molecular Structure Naproxen - chemistry Solubility Surface-Active Agents - chemistry
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Beschreibung
Zusammenfassung:	Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of poorly water-soluble drugs was studied.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c5ob00703h